DETORUBICINE


detorubicine


CAS No. 66211-92-5
Chemical Name: Detorubicin
CBNumber: CB51178460
Molecular Formula: C33H39NO14
Formula Weight: 673.66

Detorubicin is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.


Detorubicin Synonyms:

Diethoxyacetic acid 2-[(2S)-4α-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-
hexahydro-2α,5,12-trihydroxy-7-methoxy-6,11-dioxonaphthacen-2-yl]-2-oxoethyl ester
Diethoxyacetic acid 2-[(2S,4S)-4-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyloxy)-1,2,3,4,6,11-
hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxonaphthacen-2-yl]-2-oxoethyl ester
RP-33921
Detorubicin

Acetic acid, diethoxy-, 2-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-
hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl-2-oxoethyl ester
(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-
hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
Acetic acid, 2,2-diethoxy-, 2-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-
hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-oxoethyl ester

Chemical synthesis from daunorubicine hydrochloride

Preparation and experimental antitumor activity of a new semi-synthetic compound: 14-Diethoxy daunorubicin (RP 33921)
Maral, R.; et al.
Compt Rend Acad Sci 1978,443-446

detorubine
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Various info from :  https://pubchem.ncbi.nlm.nih.gov/compound/6917660

7 Associated Disorders and Diseases 
see

8 Literature
see literature references ( xml format)


8.3 Chemical Co-Occurrences in Literature
see chemical Co Occurences in Literature(xml format)

8.5 Chemical-Disease Co-Occurrences in Literature

see Chemical-Disease Co-Occurrences in Literature


Miscellaneous :

https://www.wikidata.org/wiki/Q27269295
https://pubchem.ncbi.nlm.nih.gov/compound/6917660#section=Associated-Disorders-and-Diseases