2,3 pentandione survey   dec 24

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Green chemistry journal  2024 issue 14
DOI     https://doi.org/10.1039/D4GC02097A 
 Highly efficient production of 2,3-pentanedione from condensation of bio-derived lactic acid over polymorphic ZrO2†
Neha Dhiman,ab   B. Moses Abraham, ORCID logo c   Deepti Agrawal, ORCID logo bd   Sudhakara Reddy Yenumala, ORCID logo be   Jyoti Porwald  and  Bipul Sarkar ORCID logo *ab 
Author affiliations


Funding for this research was provided by:
Indian Institute Of Petroleum, Council of Scientific and Industrial Research, India (MLP-1169)

Abstract

The demand for fermentation-based chemicals is expected to grow in the coming years because of the increasing emphasis on using bio-based chemicals over petrochemicals. Growing crude oil prices and rising concerns about carbon discharge are the main reasons pushing the shift toward bio-based chemicals. 2,3-Pentanedione is one such high-value fine chemical that is currently produced in smaller quantities through a multi-stage chemical synthesis or extracted from milk waste. Here we report a green route to produce 2,3–pentanedione directly from vapour-phase condensation of crude lactic acid over polymorphic ZrO2. The catalyst exhibits high selectivity, activity and stability for the direct condensation of raw lactic acid to 2,3-pentanedione and achieved 99.7% LA conversion and 95.5% selectivity at 325 °C.
Graphical abstract: Highly efficient production of 2,3-pentanedione from condensation of bio-derived lactic acid over polymorphic ZrO2



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Confined alkali metal ions in two-dimensional aluminum phosphate promoted activity for the condensation of lactic acid to 2,3-pentanedione

Xinli Li, Ju Zhang, Yunsheng Dai, Congming Tang and Chenglong Yang
New J. Chem., 2021,45, 13806-13813
Abstract

The intercalated alkali metal ions can efficiently mediate the acidity–basicity of the catalysts, significantly promoting the activity for LA condensation to 2,3-pentanedione.
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CID 177
178 patents from 136 patent families
View All

    Process for the preparation of 2,3-pentanedione
    US-5731471-A; Grant Date: 1998-03-24
    Molded article made of polylactic acid polymer and plasticizer for polylactic acid
    JP-5067825-B2; Grant Date: 2012-11-07
    Manufacture of lactic acid using Enterococcus sp. RKY1
    KR-100385015-B1; Grant Date: 2003-05-22


126 patents from 95 patent families
View All

    Deodorants
    JP-3789148-B2; Grant Date: 2006-06-21
    Photopolymerizable composition
    EP-0150952-B1; Grant Date: 1989-08-30
    Method for producing a flavorful and aromatic composition for use in smoking articles
    US-5962662-A; Grant Date: 1999-10-05
    
    
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    Synthesis of alpha-diketones
Publication Number: US-4107210-A  
Patent Family: US-4107210-A  
Priority Date: 1976-09-07  
Grant Date: 1978-08-15  
Inventor(s): FREITER EDWARD R  
Assignee(s): DOW CHEMICAL CO  
Classification: C07C45/72  
Abstract: Alpha-diketones, such as 1-phenyl-1,2-propanedione and 1-propyl-1,2-butanedione, are prepared by reacting an acylmethyl ester of a carboxylic acid (e.g., benzoylmethyl acetate or butanoylmethyl propionate) with an aldehyde, such as formaldehyde or acetaldehyde, in the presence of an acid catalyst and water. Such alpha-diketones are also obtained by first refluxing a mixture of an alpha-haloketone and a carboxyl anion source and then reacting the mixture with an aldehyde in the presence of an acid catalyst and water.  

cited by
Publication number Priority date Publication date Assignee Title
US4546080A * 1981-01-29 1985-10-08 Cetus Corporation Manufacture of halogenated ketones and aldehydes

Abstract

Process for the production of 2,3-pentanedione from hydroxyacetone and paraldehyde comprises reaction in the presence of an aqueous phase containing a strong organic or inorganic acid having a pKa value of no greater than 4 in the presence of a phase transfer catalyst.
US20090257973A1 * 2008-04-15 2009-10-15 Takasago International Corporation Malodor reducing composition, fragrance composition and product comprising the same


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Process for the preparation of 2,3-pentanedione
Publication Number: US-5731471-A  
Patent Family: US-5731471-A  
Priority Date: 1995-10-25  
Grant Date: 1998-03-24  
Inventor(s): MILLER DENNIS J; JACKSON JAMES E; LANGFORD ROBERT H; GUNTER GARRY C; TAM MAN SANG; ...  
Assignee(s): UNIV MICHIGAN STATE  
Classification: C07C45/00  
Abstract: A process for the preparation of purified 2,3-pentanedione from lactic compound which is lactic acid or a lactic acid ester. The process uses elevated temperatures between about 250 DEG to 370 DEG C. for heating a support (catalyst 16) and pressures between about 0.1 to 10 MPa to produce the 2,3-pentanedione in a reaction mixture. The lactic compound is converted primarily to 2,3-pentanedione, acrylic acid, and acetaldehyde at the elevated temperatures over the catalyst. The 2,3-pentanedione is preferably separated from the reaction mixture as an azeotrope with water at about 80 DEG to 90 DEG C. and then cooled to separate the 2,3-pentanedione from the water.  

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Flavoring materials and method of preparing the same  (vu)
Publication Number: US-3804953-A  
Patent Family: CA-949380-A; US-3804953-A  
Priority Date: 1970-03-05  
Grant Date: 1974-04-16  
Inventor(s): BENTZ A; SCARPELLINO R  
Assignee(s): GEN FOODS CORP  
Classification: A23L27/20  
Abstract: FOOD FLAVORING MATERIALS ARE PREPARED BY REACTING HYDROGEN SULFIDE WITH CARBONYL COMPOUNDS IN A DIKUTE AQUEOUS MEDIUM. THE FLAVORING MATERIALS ARE STABLE IN THE AQUEOUS MEDIUM AND RETAIN THEIR HIGH POTENCY AND QUALITY WHEN COMBINED WITH AN EDIBLE FIXATION AGENT AND ARE DEHYDRATED  
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Preparation of alpha-diketones
Publication Number: US-2799707-A  
Patent Family: US-2799707-A  
Priority Date: 1956-05-14  
Grant Date: 1957-07-16  
Inventor(s): DERMER OTIS C  
Assignee(s): DOW CHEMICAL CO  
Classification: C07C45/00; C07C45/52; C07C49/12; C07C49/213

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Catalytic oxidation of ketones
Publication Number: US-2393532-A  
Patent Family: US-2393532-A  
Priority Date: 1942-11-27  
Grant Date: 1946-01-22  
Inventor(s): HEARNE GEORGE W; ADAMS MERRILL L; BULS VERNON W  
Assignee(s): SHELL DEV  
Classification: B01J23/72; C07C45/33; C07C49/14; C07C49/185  
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US4107210A * 1976-09-07 1978-08-15 The Dow Chemical Company Synthesis of alpha-diketones

Abstract
Alpha-diketones, such as 1-phenyl-1,2-propanedione and 1-propyl-1,2-butanedione, are prepared by reacting an acylmethyl ester of a carboxylic acid (e.g., benzoylmethyl acetate or butanoylmethyl propionate) with an aldehyde, such as formaldehyde or acetaldehyde, in the presence of an acid catalyst and water. Such alpha-diketones are also obtained by first refluxing a mixture of an alpha-haloketone and a carboxyl anion source and then reacting the mixture with an aldehyde in the presence of an acid catalyst and water.

 ****************************************
Process for the preparation of α-diketones from ketols or ketals from ketols
Publication Number: US-6316676-B1  
Patent Family: DE-19838046-A1; EP-0983987-A1; JP-2000086565-A; US-6242653-B1; US-6316676-B1  
Priority Date: 1998-08-21  
Grant Date: 2001-11-13  
Inventor(s): AQUILA WERNER; BOTZEM JOERG; BRUNNER MELANIE; FUCHS HARTWIG; KRAUSE WOLFGANG; ...  
Assignee(s): BASF AG  
Classification: B01J23/50; C07B61/00; C07C45/37; C07C45/39; C07C45/51; ...  
Abstract: The process for the preparation of carbonyl compounds of the formula IwhereR1 and R2 are a hydrocarbon radical, orR1 and R2 together are an unsubstituted or substituted alkylene group,and X is =O or two alkoxy groups, comprises oxidizing alcohols of the formula II where R1 to R2 and X are as defined above, with oxygen in the gaseous phasea) at temperatures of from 270 to 600° C. on silver coated catalysts which comprise an abrasion-resistant coating of metallic silver on a core of inert support material, orb) at temperatures of from 450 to 750° C. on silver crystals and/or copper crystals having a particle size of from 0.1 to 2.5 mm for a residence time of at most 0.1 second.Also claimed is an advantageous overall process for the preparation of alpha-diketones, preferably diacetal, from the corresponding ketone, in particular methyl ethyl ketone, via the carbonyl compounds of the formula I where X is two alkoxy groups.  
**
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This invention relates to the catalytic oxidation of ketone alcohols and is more particularlyConcerned with reacting primary and/or secondary ketone alcohols with o
(VU) C2H5COCHOHCH3 + 02/CuO

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The invention relates to a process for the production of diketones by oxidation of glycols in the presence of a Silver and / or copper catalyst of a certain grain size and under certain conditions of temperature and catalyst composition.
example :A mixture of 254 parts of n-hexanediol-2.5 and 247 parts of air is fed to the evaporator per hour and evaporated. The vaporous starting mixture is passed through the catalyst and reacted at 650 ° C. and 1.4 bar. The load is 0.8 t / m · h. The dwell time, based on the empty tube, is 0.1 second. The gaseous reaction mixture is now cooled to 20 ° C. and then washed with water. In the form of a 49.6 percent by weight solution, 210.3 parts per hour of n-hexanedione-2.5 with a boiling point of 191 ° C., corresponding to a yield of 84.2 % of theory, no proportion of unreacted n-hexanediol-2 , 5 and 6.8 parts of hexanol-2-one-5. The space-time yield is 31> Λ g / enr · h. The life of the catalyst is 125 days, the conversion is 100 percent.
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DE2831595A1 1978-07-19 1980-01-31 Basf Ag METHOD FOR PRODUCING CARBONYL COMPOUNDS
The invention relates to a new process for the preparation of carbonyl compounds by oxidation of alcohols in Presence of a silver catalyst of a certain grain size and under certain conditions of temperature and residence time.
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DD238816A1 1985-06-27 1986-09-03 Fahlberg List Veb PROCESS FOR PREPARING MIXTURES COMPRISING BUTANE-2-OL-3-ON AND BUTANE-2,3-DION Abstract
The present invention relates to an electrochemical process for the preparation of mixtures consisting of diacetyl and acetoin by oxidation of methyl ethyl ketone. The resulting compounds are versatile intermediates. Thus, acetoin is a starting material for furan derivatives with fungicidal properties. The hitherto known chemical processes for the preparation of both compounds are associated with a high economic effort. The proposed electrosynthesis in a simple, undivided cell represents a feasible alternative variant. In laboratory experiments, good yields of diacetyl and acetoin were obtained.

Example 3 :10 g (0.135 mol) of methyl ethyl ketone are added to 90 ml of an aqueous solution containing 20% by volume of H 2 SO 4 and filled into an undivided electrolysis cell. The electrolysis is carried out at room temperature amperostatically at 1 A / dm 2 on a graphite anode and a steel cathode. The content after 10h electrolysis was determined by GC. Material yield Diacetyl = 45% Acetoin = 31%

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EP0430406A2 1989-11-28 1991-06-05 Meiji Milk Products Company Limited Method for the fermentative production of diacetyl and acetoin using lactic acid bacterium

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25/12/24

US5731471  Priority Date: 1995-10-25  Univ Michigan
This invention was made with government support under Grant No. NRI 93-37500-9585 by the United States Department of Agriculture. The government has certain rights in the invention

(1) Summary of the Invention
The present invention relates to a process for the preparation of 2,3-pentanedione by reacting lactic acid on a catalyst at elevated temperatures and then separating the 2,3-pentanedione by a unique process step which relies upon azeotropic distillation of the 2,3-pentanedione and water from the reaction mixture and cooling to separate the 2,3-pentanedione from the water. In particular, the present invention relates to a process which uses a particular group of potassium and cesium compounds as catalysts to unexpectedly produce the 2,3-pentanedione in high overall yield and selectivity.


Cited By (5)
Publication number Priority date Publication date Assignee Title
WO1998047846A1 * 1997-04-24 1998-10-29 Michigan State University Condensed phase preparation of 2,3-pentanedione
vu CN106268910A * 2016-07-19 2017-01-04 西华师范大学 The condensation of a kind of bio-based lactic acid generates the preparation method and applications of 2,3 pentanedione catalyst
vu CN107051557A * 2017-06-05 2017-08-18 西华师范大学 A kind of barium pyrophosphate load cesium-promoted catalyst and preparation method thereof, application
vu CN108658738A * 2018-04-19 2018-10-16 合肥工业大学 A kind of synthetic method of 2,3- pentanediones

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CN106268910  2016-07-19  2016-07-19 Application filed by China West Normal University
2020-07-10 CF01 Termination of patent right due to non-payment of annual fee

Abstract
The present invention relates to catalyst preparation and biomass catalyzing transformation technology field, particularly to a kind of bio-based lactic acid condensation generation 2, the preparation method of 3 pentanedione catalyst, and in catalysis lactic acid condensation preparation 2, application in 3 pentanedione techniques, ANN aluminium nitrate nonahydrate and cesium nitrate are dissolved in a certain amount of distilled water, add ammonia regulation pH to precipitate to 9 10, at 70 DEG C, agitating heating slow evaporation concentrates, and prepares the catalyst of alumina load aluminum nitrate caesium by precipitating dry, roasting subsequently.Alumina load aluminum nitrate cesium-promoted catalyst of the present invention preparation is simple, and environmental protection is with low cost, and catalysis activity is high, good stability, and 2, and the conversion ratio of 3 pentanedione selectivitys and lactic acid is high, has the highest commercial development to be worth.

Patent Citations (3)
Publication number Priority date Publication date Assignee Title
US5731471A * 1995-10-25 1998-03-24 Board Of Trustees Operating Michigan State University Process for the preparation of 2,3-pentanedione
US5831130A * 1997-04-24 1998-11-03 Board Of Trustees Operating Michigan State University Condensed phase preparation of 2,3-pentanedione
CN101579636A * 2008-05-15 2009-11-18 湖南大学 Catalyst and method for preparing 2, 3-pentanedione by lactic acid or lactate

Cited By (4)
Publication number Priority date Publication date Assignee Title
CN106824236A * 2017-02-21 2017-06-13 西华师范大学 Caesium or the hydroxyapatite catalyst of calcic of potassium doping and its preparation method and application
CN107051557A * 2017-06-05 2017-08-18 西华师范大学 A kind of barium pyrophosphate load cesium-promoted catalyst and preparation method thereof, application
CN107129551A * 2017-05-05 2017-09-05 佛山市飞时达新材料科技有限公司 A kind of preparation method based on the polystyrene microsphere that 2,3 pentanediones are light trigger
CN108658738A * 2018-04-19 2018-10-16 合肥工业大学 A kind of synthetic method of 2,3- pentanediones

CN106268910A 2017-01-04 The condensation of a kind of bio-based lactic acid generates the preparation method and applications of 2,3 pentanedione catalyst
CN105330523A 2016-02-17 Method for preparing cyclopentanone by taking biomass resource as raw material
CN102631930A 2012-08-15 Catalyst for preparing furfuryl alcohol from furfural by vapor phase hydrogenation and preparation method thereof
CN201610571130.XA 2016-07-19 A kind of preparation method and applications of bio-based lactic acid condensation generation 2,3- pentanedione catalyst

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 CN108658738   Current Assignee     Hefei University of Technology
 2018-04-19 Application filed by Hefei University of Technology
 
Abstract
The present invention relates to a kind of synthetic methods of 2,3 pentanedione.Lactic acid solution is mixed and be catalyzed under the conditions of 100~400 DEG C with solid base catalyst M/N by the present invention to react 2~10 hours, obtains 2,3 pentanediones；Wherein M is active cargo and is K2CO3、KHCO3、KNO3、KPO4, any one of KF, N is carrier and is Al2O3, zeolite molecular sieve, ZrO2Any one of, the molar ratio of the active cargo and carrier is 1：(0.1~10)；The mass ratio of the solid base catalyst M/N and lactic acid is 1:(5~100).The present invention is using support type super base as catalyst, and catalysis lactic acid synthesizes 2,3 pentanediones, and the present invention can obtain higher selectivity and conversion ratio, and the yield for directly synthesizing 2,3 pentanediones reaches 60~80%.


Embodiment 1
(1) preparation of solid base
2.9gKF is weighed, is added in beaker, 20ml water, stirring is added, then weigh 6.2gAl2O3It is added in above-mentioned solution (KF and Al2O3Molar ratio be 1:1.2) 60 DEG C of stirring 1h, are heated to, mixture is obtained, obtained mixture is put into vacuum The dry 12h of 50~60 DEG C of drying box obtains solid super basic catalyst to get unactivated.Under nitrogen atmosphere by above-mentioned solid 350~550 DEG C of activation process 4h, the solid super basic catalyst activated.
(2) 2,3- pentanediones are catalyzed and synthesized
75g lactic acid solutions (content 90%) and the solid base catalyst of the above-mentioned preparations of 5g is taken to mix, slowly heating reaction is mixed Object is closed, when reaction temperature reaches 200 DEG C, lactic acid carries out condensation dehydration decarboxylic reaction, generates 2,3- pentanediones.Meanwhile it generating 2,3- pentanediones and water vaporized from reaction mixture, after being cooled down by condenser pipe, collection obtain 2,3- pentanediones and water Fraction.As reaction constantly carries out, kettle temperature slowly increases, and goes out to evaporate and slows, until being steamed without apparent fraction, stops heating, Reaction was completed.Collect obtained 2,3- pentanediones and aqueous distillate stratification；After lower layer's water phase is extracted with ethyl acetate and upper layer 2,3- pentanediones merge, and are fractionated organic phase, recycling design, and rectifying obtains 28.15g 2,3- pentanediones, yield 81.5%.2, 3- pentanediones are through gas chromatographic detection, and content is up to 99% or more.


Cited By (2)
Publication number Priority date Publication date Assignee Title
vu CN112811982A * 2020-12-30 2021-05-18 中国科学院长春应用化学研究所 Synthetic method of pentanediol and synthetic method for preparing biomass-based linear pentadiene based on lactic acid conversion
CN115109246A * 2022-07-01 2022-09-27 佳化化学科技发展（上海）有限公司 Alkynyl alcohol ether and preparation method and application thereof

Similar Documents
CN108658738A 2018-10-16 A kind of synthetic method of 2,3- pentanediones

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CN112811982  2020-12-30  Application filed by Changchun Institute of Applied Chemistry of CAS

Abstract
The invention provides a method for synthesizing pentanediol, which comprises the following steps of carrying out hydrogenation reaction on mixed liquid obtained by mixing pentanedione, a hydrogenation catalyst and an organic solvent in an atmosphere containing hydrogen to obtain the pentanediol. The invention can utilize bulk bio-based chemical lactic acid which is cheap and easy to obtain the pentanediol, and further obtain the linear pentadiene. The raw materials in the invention are derived from renewable resources, and linear pentadiene is obtained by (1) condensing lactic acid to prepare pentanedione, (2) hydrogenating the pentanedione to prepare pentanediol, and (3) dehydrating the pentanediol. The invention prepares linear pentadiene, especially 1, 3-pentadiene, by the technological route of condensation, hydrogenation and dehydration of lactic acid. The invention provides a method for green and sustainable synthesis of linear pentadiene based on bio-based chemical conversion, which has the advantages of simple operation, short flow, no need of harsh experimental conditions, easy preparation of raw materials and catalysts, and large-scale synthesis prospect.

Example 1
(1) And (3) condensation of lactic acid to prepare pentanedione:
weighing 2.0g of sodium bicarbonate to prepare 5ml of solution, adding 5g of MgO under the stirring condition, standing for 12h, and drying at 120 ℃ for 10 h. The MgO is roasted for 4 hours at 550 ℃ before use to obtain the condensation catalyst. Weighing 1.5g of catalyst, and filling the catalyst into a fixed bed reactor; before the reaction, the catalyst is treated at 550 ℃ for 3 hours preferably; during the reaction, the raw material feeding rate is 0.06ml/min, the nitrogen flow rate is 60ml/min, and the reaction temperature is 380 ℃. The pentanedione yield was 73% and the conversion of the starting material was 89%.

(2) And (3) hydrogenation of pentanedione to prepare pentanediol:
mixing Al2O3Roasting the carrier at 500 ℃ for 5h, weighing 3.0g of the carrier in a beaker, adding 3ml of chloroplatinic acid solution, stirring for 10min, standing overnight, drying in a 120 ℃ oven for 8h, roasting at 450 ℃ for 4h, and treating at 300 ℃ for 4h in hydrogen atmosphere to obtain Pt/Al2O3The loading amount of Pt of the hydrogenation catalyst is controlled to be 1.0 percent. 0.8g of hydrogenation catalyst is weighed into a stainless steel high-pressure reaction kettle with a tetrafluoro liningAdding pentanedione 10g and diluting with isopropanol to 50ml, charging with H2Replacing 3 times, and pressurizing 4MPaH2The reaction temperature was set at 80 ℃ and the reaction time was set at 4 h. The yield of pentanediol was 84% and the conversion of pentanedione was 89%.

(3) And (3) dehydrating pentanediol to prepare linear pentadiene:
weighing 20g of lanthanum nitrate in a 500ml round-bottom flask to prepare a solution, dropwise adding ammonia water until a large amount of precipitate appears, filtering, washing and filtering, then adding 200ml of phosphoric acid (the concentration is 1.2mol/L), stirring at 50 ℃ for 10h, standing for 12h, filtering, drying at 120 ℃, and roasting at 800 ℃ for 6h to obtain LaP catalyst. Weighing 2.0g of LaP catalyst, loading the LaP catalyst into a fixed bed reactor, and treating the LaP catalyst for 4 hours at 500 ℃ in a nitrogen atmosphere before reaction; during the reaction, the raw material feeding rate is 0.05ml/min, the nitrogen flow rate is 65ml/min, and the reaction temperature is 500 ℃. The yields of 1, 4-pentadiene and 1, 3-pentadiene obtained were 52%, with a yield of 1, 3-pentadiene of 45% and a conversion of pentanediol of 96%.

Example 4
(1) And (3) condensation of lactic acid to prepare pentanedione:
1.8g of sodium bicarbonate is weighed out to prepare a 5ml solution, 5g of TiO is added under stirring2Standing for 12h, and drying at 120 ℃ for 10 h. TiO before use2Calcining at 580 deg.C for 5h to obtain the condensation catalyst. Weighing 1.5g of catalyst, and filling the catalyst into a fixed bed reactor; before the reaction, the catalyst is treated at the temperature of 430 ℃ for 4 hours preferably; during the reaction, the raw material feeding rate is 0.08ml/min, the nitrogen flow rate is 70ml/min, and the reaction temperature is 380 ℃. The pentanedione yield obtained was 61%, and the conversion of the starting material was 90%.



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EP0983987A1 * 1998-08-21 2000-03-08 Basf Aktiengesellschaft Process for the preparation of alpha-diketones from ketols or from ketals of ketols
EP1826194A1 * 2004-11-19 2007-08-29 Shanghai Apple Flavor&Fragrance Co. Ltd. A preparation method of butadione by gas-phase oxidatiing 3-hydroxy-butanone
US10259766B1 * 2018-12-07 2019-04-16 Huaiyin Institute Of Technology Preparation method for 2,3-pentanedione



*****************************************synthesis hydroxyaceton alias acetol*****************


EP1948582B1

2006-10-31  Application filed by University of Missouri System

Abstract
A reactive-separation process converts glycerin into lower alcohols, having boiling points less than 200° C., at high yields. Conversion of natural glycerin to propylene glycol through an acetol intermediate is achieved at temperatures from 150° to 250° C. at pressures from 1 and 25 bar. The preferred applications of the propylene glycol are as an antifreeze, deicing compound, or anti-icing compound. The preferred catalyst for this process in a copper-chromium.
WO 2005/095536 A2 discloses a process for converting glycerol to acetol with high selectivity, comprising combining a glycerol-containing feedstock with less than 50% by weight water with a catalyst that is capable of dehydrating glycerol, to form a reaction mixture, and heating the reaction mixture to a temperature ranging from 150° to 250°C over a reaction time interval ranging from more than 0 to 24 hours at a pressure ranging from 0.2 and 25 bar.

US8809593B2 * 2010-02-26 2014-08-19 Council Of Scientific And Industrial Research Process for preparation of hydroxyacetone or propylene glycol

US8975453B2 2012-03-13 2015-03-10 University Of Idaho Catalytic conversion of glycerol or acetol to alcohols
EP2540692B1 2016-04-06 Production of propylene glycol from glycerol

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US8809593B2 * 2010-02-26 2014-08-19 Council Of Scientific And Industrial Research Process for preparation of hydroxyacetone or propylene glycol

Abstract
The present invention relates to a process for the preparation of the hydroxyacetone or 1,2 propylene glycol. More particularly, the present invention relates to a process for preparation of hydroxyacetone or 1,2 propylene glycol by glycerol. Further, the said process is catalyzed by metal catalysts that results in 80 to 100% selectivity towards conversion of glycerol to hydroxyacetone (acetol) or 1,2 propylene glycol (1,2 PG).

CN109772344A * 2017-11-14 2019-05-21 A kind of copper-based catalysts, its manufacturing method and its application
CN109896940A * 2017-12-07 2019-06-18 A kind of Zinc oxide-base catalyst is used for hydroxypropanone- synthetic method

CN118388331A * 2024-05-07 2024-07-26 山东极地医药科技有限公司 Production process of hydroxyacetone

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CN118388331A * 2024-05-07 2024-07-26 山东极地医药科技有限公司 Production process of hydroxyacetone

Abstract

The invention relates to a production process of hydroxyacetone, which relates to the technical field of chemical synthesis, and comprises the steps of uniformly mixing glycerol, an organic solvent and a supported catalyst, reacting at 170-220 ℃ for at least 2 hours, filtering to obtain filtrate and solid, rectifying the filtrate to obtain hydroxyacetone, wherein the supported catalyst is prepared by adopting an impregnation method and comprises 20-40% of active components and 60-80% of carriers, the active components of the supported catalyst comprise aluminum, copper, chromium and zinc, and the carriers comprise aluminum oxide, zeolite, zirconium dioxide and calcium oxide. The invention can improve the conversion rate of glycerol, improve the selectivity and purity of hydroxyacetone, prolong the service life of the catalyst and further improve the production efficiency of hydroxyacetone.


CN202410556065.8A 2024-05-07 Production process of hydroxyacetone